SELECTED PUBLICATIONS

  • Mouchiroud, M., C. Camiré, M. Aldow, A. Caron, E. Jubinville, L. Turcotte, et al., The hepatokine Tsukushi is released in response to NAFLD and impacts on cholesterol homeostasis, JCI Insight, In press, 2019.

  • Besse-Patin A, Jeromson S, Levesque-Damphousse P, Secco B, Laplante M, Estall JL. PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin.Proc Natl Acad Sci U S A. 2019 Feb 15

  • Caron A, Briscoe DM, Richard D, Laplante M. DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.Physiol Rev. 2018 Jul 1;98(3):1765-1803. 

  • Wilson AM, Shao Z, Grenier V, Mawambo G, Daudelin JF, Dejda A, Pilon F, Popovic N, Boulet S, Parinot C, Oubaha M, Labrecque N, de Guire V, Laplante M, Lettre G, Sennlaub F, Joyal JS, Meunier M, Sapieha P. Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome.Sci Immunol. 2018 Mar 16;3(21).

  • Caron A, Mouchiroud M, Gautier N, Labbé SM, Villot R, Turcotte L, Secco B, Lamoureux G, Shum M, Gélinas Y, Marette A, Richard D, Sabatini DM, Laplante M. Loss of hepatic DEPTOR alters the metabolic transition to fasting.Mol Metab. 2017 Feb 17;6(5):447-458.  

  • Secco B, Camiré É, Brière MA, Caron A, Billong A, Gélinas Y, Lemay AM, Tharp KM, Lee PL, Gobeil S, Guimond JV, Patey N, Guertin DA, Stahl A, Haddad É, Marsolais D, Bossé Y, Birsoy K, Laplante M. Amplification of Adipogenic Commitment by VSTM2A. Cell Rep. 2017 Jan 3;18(1):93-106.

 

  • Labbé SM, Mouchiroud M, Caron A, Lamoureux G, Gélinas Y, Freinkman E, Leconte R, Bossé Y, Chimin P, Festuccia WT, Richard D, Laplante M*. mTORC1 is required for brown adipose tissue recruitment and metabolic adaptation to cold. Scientific Reports, 2016

 

  • Caron A, Labbé SM, Mouchiroud M, Huard R, Richard D*, Laplante M*. (2016) DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance. Am J Physiol Regul Integr Comp Physiol, 2016 Jun 1;310(11):R1322-31 (*co-corresponding).

 

  • Carbonneau M, Germain AM, Gagné L, Lalonde ME, Motorina A, Guiot MC, Secco B, Vincent E, Tumber A, Hulea l, Oppermann U, Jones R, Laplante M, Toposirovic I, Petreca K, Huot ME, Mallette FA. (2016) The oncometabolite 2-hydroxuglutarate activates the mTOR signaling pathway. Nature Communications

 

  • Labbé SM, Caron A, Chechi K, Laplante M, Lecomte R, Richard D. (2016) Metabolic activity of brown, beige and white adipose tissues in response to chronic adrenergic stimulation in male mice. Am J Physiol Endocrinol Metab, 2016 Jul 1;311(1):E260-8

 

  • Caron A, Labbé SM, Lanfray D, Blanchard PG, Sabatini DM, Richard D*, Laplante M* (2016). Hypothalamic Deptor overexpression protects against high-fat diet induced obesity. Molecular Metabolism, 8; 5 (2):102-12. (*co-corresponding)

 

  • Lanfray D, Caron A, Roy MC, Laplante M, Morin F, Leprince J, Tonon MC, Richard D. (2016) Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice. Elife, 2016 Feb 15;5. pii: e11742. doi: 10.7554/eLife.11742.

 

  • Caron A, Richard D, Laplante M (2015). The roles of mTOR complexes in lipid metabolism. Annu Rev Nutr., 2015;35:321-48.

 

  • Sood A, Jeyaraju DV, Prudent J, Caron A, Lemieux P, McBride HM, Laplante M, Toth K, Pellegrini L (2015). A mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver. Proc Natl Acad Sci U S A, 11; 111(45).

 

  • Caron A, Baraboi ED, Laplante M*, Richard D* (2015). DEP domain containing mTOR-interacting protein in the rat brain : distribution of expression and potential implications. J Comp Neurol. Jan 1;523(1):93-107. doi: 10.1002/cne.23668. (*co-corresponding)

  • Festuccia WT, Pouliot P, Bakan I, Sabatini DM, Laplante M* (2014) Myeloid-specific rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PLoS One 9: e95432. (*co-corresponding)

 

  • Laplante M, Sabatini DM (2013) Regulation of mTORC1 and its impact on gene expression at a glance. J Cell Sci 126: 1713-1719.

 

  • Birsoy K, Festuccia WT, Laplante M (2013) A comparative perspective on lipid storage in animals. J Cell Sci 126: 1541-1552.

 

  • Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149: 274-293.

 

  • Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, et al. (2012) DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity. Cell Metab 16: 202-212.

 

  • Bakan I, Laplante M (2012) Connecting mTORC1 signaling to SREBP-1 activation. Curr Opin Lipidol 23: 226-234.

 

  • Laplante M, Sabatini DM (2011) mTOR Signaling. Cold Spring Harb Perspect Biol. Feb 1;4(2). pii: a011593. doi: 10.1101/cshperspect.a011593. 

 

  • Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM (2010) mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468: 1100-1104.

 

  • Laplante M, Sabatini DM (2010) mTORC1 activates SREBP-1c and uncouples lipogenesis    from gluconeogenesis. Proc Natl Acad Sci U S A 107: 3281-3282.

 

  • Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, et al. (2009) DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137: 873-886.

 

  • Laplante M, Sabatini DM (2009) mTOR signaling at a glance. J Cell Sci 122: 3589-3594.